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Author

David Lalaouna

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3 papers indexed here

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Open access Sep 2026

A Zur-dependent regulatory RNA involved in maintaining zinc homeostasis in Staphylococcus aureus

Abstract Small regulatory RNAs (sRNAs) are key drivers of bacterial adaptation to environmental fluctuations, including iron and manganese restriction imposed by the host. This study explored the repertoire of sRNAs produced by the human pathogen Staphylococcus aureus in response to metal limitation. Two sRNAs were ide...

Mathilde Charbonnier, Hugo Racine, Samuel Probst-Lotze et al. · 0 citations
Aug 2026

Seed pairing between a small regulatory RNA and target mRNA determines cleavage by a RNase E with a minimal C-terminal scaffold.

Small regulatory RNAs (sRNAs) can specifically bind to their target mRNAs to inhibit their expression, either by promoting degradation or by blocking translation. However, the molecular determinants that select which repression mode an sRNA employs remain poorly understood. To investigate this, we used the model target...

Carlos Daniel Vega Valle, Karine Prévost, David Lalaouna et al. · 0 citations
Open access Aug 2026

Peptidoglycan remodeling prevents antibiotic resistance during oxidative stress

The results suggest that reactive oxygen species (ROS), in conjunction with intracellular iron, play a key role in driving the emergence of antibiotic resistance.

Jonathan Sukadi Miala, Léanne Arcand-Carrier, Rosalie Lapointe et al. · 0 citations

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