Open access
Mar 2025
Diversity and evolution of chromatin regulatory states across eukaryotes
A combinatorial indexing ChIP-seq method is developed to simultaneously profile specific hPTMs across diverse eukaryotic lineages, suggesting that while core hPTMs are ancient and broadly conserved, their functional readout has diversified throughout eukaryotic evolution, shaping lineage-specific chromatin landscapes.
Cristina Navarrete, Sean A. Montgomery, Julen Mendieta et al.
· bioRxiv · 11 citations
· ⚡4