David Lim

Macrophage polarization regulated by the βTrCP-NF-κB inflammatory signaling pathway is required for valproic acid’s dual role in breast tumor radiosensitivity and normal tissue radioprotection

It is demonstrated that VPA enhances the radiosensitivity of breast tumor by activating the βTrCP-NF-κB immune pathway, which reprograms tumor-associated macrophages (TAMs) into the M1 phenotype, revealing a novel immunological mechanism for its application as a RT adjuvant.