Author

David M. Holtzman

2 papers indexed here

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Open access Jul 2026

Lecanemab in symptomatic PSEN1 p.Met233Val early‐onset Alzheimer's disease: Neuroimaging safety, regional amyloid‐PET dynamics, and longitudinal plasma biomarkers

Abstract Introduction The presenilin 1 (PSEN1) p.Met233Val variant is a Dominantly Inherited Alzheimer Network–Trials Unit (DIAN‐TU)–eligible autosomal‐dominant Alzheimer's disease (ADAD) variant for which lecanemab response data are unavailable. Methods A 34‐year‐old symptomatic PSEN1 p.Met233Val carrier (APOE ε3/ε3)...

Min-Young Noh, Wonjae Sung, Hyunkee Kim et al. · Alzheimer's & Dementia · 0 citations

Open access Jul 2026

Ms4a4a loss reprograms amyloid-associated microglia and limits dense-core plaque-associated tau spreading

INTRODUCTION Microglia regulate amyloid plaque-associated microenvironments that contribute to downstream tau pathology in Alzheimer’s disease (AD). Variants within the MS4A locus are strongly associated with AD risk and resilience and are linked to microglial biology; however, the functional role of MS4A4A in plaque-a...

E. Danhash, Shao-Yu Fang, Jacob A. Marsh et al. · bioRxiv · 0 citations