Author

David M. Holtzman

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Open access Sep 2026

Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome.

Disease-related activation of glial cells leads to changes in the cerebrospinal fluid (CSF) proteome. However, assigning such protein changes to their cellular origins is often difficult. Here, we used microglia (and macrophage) depletion in mice to identify CSF proteins of microglial origin. Young mice were treated wi...

Sinja Buchner, Si-Hui Song, Stephan A. Mueller et al. · Proteomics · 0 citations

Open access Sep 2026

The sphingosine-1-phosphate receptor functional antagonist fingolimod exacerbates neuroinflammation and tau pathology in a mouse model of tauopathy

Objective T cells are increased in the brain in Alzheimer’s disease (AD) and primary tauopathies where they correlate with tau pathology. In mouse models, T cells exacerbate tau-related neuroinflammation and neurodegeneration, and depletion of T cells is neuroprotective. Here, we investigate whether the multiple sclero...

M. Rudman, Alexandra Litvinchuk, Cathryn Smith et al. · bioRxiv · 0 citations