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Author

David Zong

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Oct 2026

Tn7 Integration Efficiently Introduces Gene Expression Cassettes into a Gut-Native Escherichia coli Strain

Native bacteria are strains isolated from the host and often require greater development and optimization of genetic manipulation tools than lab-adapted strains. We have previously shown that the native murine Escherichia coli strain EcAZ-1, which colonizes the conventional mouse gut long term, is genetically tractab...

David M. Zong, Sharyl Bailey, Zainab Fatima et al. · 0 citations
Review Jul 2026

Engineering commensal microbes for host health.

This review summarized recent progress in the development of eLBPs across diverse disease indications, including inflammatory diseases, metabolic disorders, cancer, and infectious diseases, and proposed framework for the rational design of next-generation eLBPs that can more reliably translate from experimental systems...

Elizabeth A. Brown, Arianna Brevi, David Zong et al. · 0 citations

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