Abstract IA01: New frontiers in childhood cancer predisposition: Harnessing genomics for early detection and tumor interception
The challenges and opportunities for early cancer detection and interception in the context of pediatric cancer predisposition are exemplified by the paradigm cancer predisposition disorder, Li-Fraumeni syndrome. More than 85% of patients with Li-Fraumeni Syndrome harbour germline TP53 mutations. The genetic and phen...