Open access
Oct 2026
Priming of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming and functional impairments in iPSC-derived cardiomyocytes
How Doxorubicin (Dox) mediated damage to stem cells or cardiomyocytes contributes to cardiotoxicity and cardiac regeneration is unclear. Using a human iPSC-based model together with corresponding iPSC-derived cardiomyocytes (iCMs) revealed that iPSCs are much more sensitive against single short pulse-treatments with Do...
Michelle Westerhoff, Roohallah Ghodrat, Nahal Brocke-Ahmadinejad et al.
· npj Regenerative Medicine · 0 citations