Author

David S. Rueda

2 papers indexed here

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Open access Sep 2026

Negative supercoiling facilitates human TOP3α-mediated decatenation of DNA braids via catenation junction melting

DNA catenation between sister chromatids arises during replication and must be efficiently resolved to ensure faithful chromosome segregation. The removal of DNA catenation is generally attributed to the type II topoisomerase TOP2α, which catalyses double-stranded DNA passage reactions and can therefore directly remove...

Sanjana Saravanan, Anno I. Koetje, Graeme A. King et al. · bioRxiv · 0 citations

Open access Sep 2026

INO80 rapidly shuttles nucleosomes between chromatin barriers

ATP-dependent chromatin remodelers establish nucleosome organization, but how they move nucleosomes over extended distances and respond to neighboring chromatin remains unclear. Here, we combine correlative optical tweezers and fluorescence microscopy, and single-molecule FRET to visualize human INO80 activity on naked...

Benjamin Ambrose, Paul Girvan, Michael T. Skehan et al. · bioRxiv · 0 citations