Open access
Aug 2026
NU7441 reveals DNA-PK and BRD4 convergence as a therapeutic vulnerability in ovarian cancer
BRD4 and DNA-PK play critical roles in regulating DNA repair, genome integrity, and cellular growth and proliferation, highlighting their potential as targets for cancer therapy. BRD4 is upregulated in multiple cancers, including ovarian cancer, where its expression increases during tumor development and correlates w...
Julie A. Disharoon, Brandon C. Johnson, Elizabeth A. Ampolini et al.
· BMC Cancer · 0 citations