Open access
Aug 2026
Closing the fusion-detection gap in single-cell RNA-seq with a scalable, probe-based workflow
Single-cell RNA-sequencing resolves cellular states in exquisite detail. Yet oncogenic gene fusions, key drivers in 16.5% of malignancies and ∼50-70% of acute lymphoblastic leukaemia (ALL) cases, remain largely invisible at this resolution. This leaves a fundamental gap in understanding cancer biology. We close it with...
Jovana Maksimovic, Victoria Streeton-Cook, Calandra V. Grima et al.
· bioRxiv · 0 citations