Davide Capodanno

Omega-3 Fatty Acids in the Management of Cardiovascular Disease Prevention.

PURPOSE Omega-3 polyunsaturated fatty acids lower triglycerides and modulate inflammation, thrombosis, and endothelial function, providing a rationale for their use in cardiovascular prevention. This review examines the influence of formulation, dose, and patient selection on clinical outcomes. METHODS A targeted Pub...

Sex-based differences in acute coronary syndrome: mechanisms, management, and outcomes.

INTRODUCTION Acute coronary syndrome (ACS) remains a leading cause of morbidity and mortality worldwide. Sex- and gender-related differences in ACS persist and encompass risk profiles, clinical presentation, management, and outcomes. AREAS COVERED PubMed was searched from database inception through May 2026 for relev...

Catheter-Based Left Atrial Appendage Closure vs Oral Anticoagulation in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis.

Importance In patients with atrial fibrillation (AF), oral anticoagulation (OAC) is the gold standard for preventing ischemic stroke, at the expense of a higher risk of bleeding. Catheter-based left atrial appendage closure (LAAC) has been proposed as an alternative strategy to prevent stroke, but the efficacy and safe...

Comparison of the 2025 ESC/EAS and 2026 ACC/AHA Guidelines for Dyslipidemia Management.

Anticoagulant regimen for non-valvular atrial fibrillation in the elderly and frail population.

In elderly and frail patients with AF, DOACs represent the first-line anticoagulant therapy when appropriately dosed and monitored, and future trials specifically enrolling very old and severely frail patients are urgently needed to close existing evidence gaps.