The TLR4/MyD88 axis in cancer: divergent and convergent roles of NF-κB and NLRP3 inflammasome activation and therapeutic opportunities.
The TLR4/MyD88 signaling axis serves as a central hub linking microbial- and damage-associated molecular patterns to oncogenic inflammation. Upon ligand engagement, MyD88 orchestrates two major downstream branches, including the canonical NF-κB pathway, which drives transcriptional programs for cell survival, prolifera...