Author

De Chen

3 papers indexed here

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Review Open access Sep 2026

The role of the gut–lung axis in persistent inflammation and disease progression in chronic obstructive pulmonary disease: mechanistic evidence and therapeutic implications

Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic respiratory disease worldwide, and the mechanisms underlying its persistent airway inflammation, systemic inflammation, and acute exacerbations remain incompletely understood. In recent years, the concept of the gut-lung axis has provided a new...

Cheng-Zu Zhang, Qin-Zu Zhang, Lei Zhang et al. · Frontiers in Immunology · 0 citations

Review Open access Sep 2026

Childhood asthma and the microbiome: from gut-lung axis mechanisms to precision prevention strategies

Childhood asthma is a highly heterogeneous chronic respiratory disease, and its onset and progression are intricately linked to genetic susceptibility, environmental exposure, immune development, and the establishment of the early-life microbiome. In recent years, studies on the gut and respiratory microbiomes have sug...

Xuan Liang, De Chen, Jia-Fen Hu et al. · Frontiers in Immunology · 0 citations

Sep 2026

Mitochondrial Reverse Electron Transfer Contributes to Oxidative Damage in Sepsis-Induced Cardiomyopathy.

Sepsis-induced cardiomyopathy (SICM) is a severe complication of sepsis characterized by myocardial depression and high mortality, yet the underlying mechanisms remain incompletely understood. Here, we provide evidence supporting reverse electron transfer (RET) at mitochondrial complex I as a contributing pathogenic me...

Nan-Nan He, Ting Zhao, Xiong-Xiong Liu et al. · Free Radical Biology & Medic... · 0 citations