Author

De-Fan Wang

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Review Open access Oct 2026

Role of Hypoxia-Inducible Factor-1 Alpha in Endometrial Decidualization

Endometrial decidualization is a hormonally programmed differentiation and tissue-remodeling process that prepares the endometrium for embryo implantation and supports early pregnancy. It involves coordinated changes in endometrial stromal cells, the extracellular matrix, vascular function, metabolism, and local immune...

De-Fan Wang, Zheng-Hong Zhang, Ren-Feng Xu et al. · Biomolecules · 0 citations

Review Open access Sep 2026

The Succinate–HIF-1α–NLRP3 Axis in 3-Nitropropionic Acid-Induced Ovarian Dysfunction: A Testable Metabolic–Inflammatory Framework

Simple Summary 3-Nitropropionic acid (3-NPA) is a mitochondrial toxin that inhibits succinate dehydrogenase and can cause reproductive and ovarian injury. Although direct studies have shown that 3-NPA exposure can increase oxidative stress, impair mitochondrial function, promote granulosa-cell apoptosis, disrupt follic...

Zheng-Hong Zhang, De-Fan Wang, Qing-He Lin et al. · Biology · 0 citations

Review Open access Aug 2026

The potential role of NLRP3 inflammasome in integrating redox, metabolic, and inflammatory signals during follicular development: a hypothesis-driven redox-metabolic integrator framework

A hypothesis-driven framework is proposed in which NLRP3 may act as a candidate redox-metabolic integrative node that coordinates stress-related signals within the follicular microenvironment and may contribute to developmental transitions including follicular growth, dominance acquisition, ovulatory competence, and at...

Zheng-Hong Zhang, De-Fan Wang, Qing-Qiang Lin et al. · Frontiers in Cell and Develo... · 0 citations