Autophagic stress-induced nanomedicine potentiates radioimmunotherapy against liver cancer through cGAS-STING signaling and immune remodeling.
Radioimmunotherapy is increasingly recognized as an immune-activating modality. However, its therapeutic efficacy in hepatocellular carcinoma (HCC) remains unsatisfactory. Herein, a hyaluronic acid (HA)-modified, HCQ-loaded ZIF-8@MnOx nanoplatform (HCQ@ZIF-8@MnOx@HA, CZMH) is engineered to induce autophagic stress for...