Author

De-Sheng Wu

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Review Open access Sep 2026

Precision medicine in rheumatoid arthritis: advances and clinical applications of multi-omics biomarkers

This paper analyzes the challenges faced by multi-omics biomarkers during clinical translation, including technical barriers, cost-effectiveness, and standardization, and critically evaluates the nascent integration of spatialomics and liquid biopsy technologies within the “multi-omics + AI” framework.

De-Sheng Wu, Li-Hung Chang, Juan Chai · Frontiers in Immunology · 0 citations

#artificial intelligence Preprint Aug 2026

Agentic AI uncovers conserved cross-tissue protein co-abundance programs inaccessible to single-dataset analysis

An LLM-agent framework is presented for large-scale, evidence-grounded comparison of tissue-specific protein co-abundance networks and a hypothesis-generating resource for mechanistic and therapeutic exploration of conserved protein co-abundance is provided.

Run-Yun Guan, Desheng Wu, Qizheng Xie et al. · 0 citations

Open access Jul 2026

Single-Cell Transcriptomic Characterization of the Tumor Microenvironment in Prostate Cancer Bone Metastases.

This study provides comprehensive insights into the cellular composition and molecular architecture of the PCa bone metastatic TME, revealing distinct cell populations, type-specific gene signatures, and cell-cell communication networks driving bone metastasis progression.

Jun Zhao, De-Sheng Wu · SLAS technology · 0 citations