Doxorubicin (DOX) resistance limits the efficacy of chemotherapy in breast cancer, and suppression of ferroptosis may contribute to this process. This study investigated the role of the Tumor Protein P53 (P53)/E1A‐associated protein P300 (P300)/Hypoxia‐inducible factor‐1α (HIF‐1α)/Transferrin Receptor (TFRC) axis in re...
Xiao-Jie Yu, L. Yao, Shu-Chun Zhang et al.· The FASEB Journal· 0 citations
The widespread adoption of contemporary human epidermal growth factor receptor 2 (HER2)-targeted therapies has altered survival in HER2-positive metastatic breast cancer, potentially limiting the applicability of older prognostic models. We aimed to develop and internally validate nomograms for overall survival (OS) an...
Curcumin, a natural compound from Curcuma longa, exerts anti-tumor activity in breast cancer, but the exact mechanism remains unclear. This study, after exposing to curcumin (0, 10, 30, and 60 μM), MTT, CCK-8 assays, and Flow cytometry analyzed human breast cancer cell viability, proliferation, and apoptosis. miR-181b...
Feng-Lin Cai, Xue-Na Geng, Hang Su et al.· Boletin Latinoamericano y de...· 0 citations
A previously unrecognized transcription‐ubiquitination cascade that modulates Hippo signaling and contributes to breast cancer progression is revealed, highlighting this axis as a candidate therapeutic vulnerability that warrants further validation for limiting metastasis.
An Xu, Xiang-nan Xu, Xiao Huang et al.· Advancement of science· 0 citations
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