Open access
Oct 2026
A Nanomechanical Fingerprint of Centromeric Methylation Co-Localization in TNBC Chromosomal Instability
Centromeric heterochromatin is maintained by a self-reinforcing loop between DNA methylation (5mC) and histone H3 lysine 9 trimethylation (H3K9me3), yet whether this coupling is preserved at the level of individual chromosomes in cancer has been inaccessible to conventional epigenomic assays, which average signals acro...
Tanya Agrawal, Shoubhik Chakraborty, S. Khanna et al.
· bioRxiv · 0 citations