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Author

Debdeep Dutta

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Review Open access Oct 2026

The emerging role of ER-localized TMEM proteins in neurodevelopmental disorders.

The known cellular functions of ER-resident TMEM proteins are discussed, evidence linking their dysfunction to neurodevelopmental phenotypes is summarized, and emerging mechanisms by which ER-resident TMEM proteins may contribute to NDD pathogenesis are highlighted.

Shreni Priyadarshini, Rishi Kumar, Debdeep Dutta · 0 citations
Open access Jul 2026

Epilepsy-associated digenic variants affecting an actin/mitochondria/glutamate pathway promote seizure susceptibility

The AMG pathway is established as a mechanistic framework for identifying digenic etiologies in epilepsy and highlight potential therapeutic targets after it was demonstrated that reduced actin polymerization promoted DRP1-mediated mitochondrial fission, increased ROS levels, and enhanced glutamatergic transmission, le...

Shenzhao Lu, Mengqi Ma, Shabab B. Hannan et al. · 0 citations

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