Prognostic impact of her2-low status in patients with breast cancer: a systematic review of the literature
Introduction: Breast cancer (BC) is a biologically heterogeneous disease and HER2 expression presents important prognostic implications. Recently, the HER2-low BC has been recognized, defined as HER2 immunohistochemistry (IHC) 1+ or 2+ without gene amplification, whereas HER2-zero tumors show no detectable expression....