Author

Dechun Geng

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Aug 2026

Protein phosphatase 2A regulates nucleus pulposus autophagy and aggravates degeneration via the AKT/mTOR pathway.

It is proposed that PP2Ac induces autophagy in NP cells by activating the AKT/mTOR pathway, thereby facilitating NP degeneration.

Yi-Jie Liu, Yu-Jie Wang, Hong Zhou et al. · International Journal of Bio... · 0 citations

Jul 2026

The USP5-MATN3 axis in nucleus pulposus cell senescence: A Deubiquitination mechanism protecting against intervertebral disc degeneration.

This study clarifies the molecular mechanism by which the USP5/MATN3 axis regulates cellular senescence and affects IVDD progression, opening up new potential targets for the intervention strategy of IVDD.

Chunyang Fan, Jie-yun Xia, Yao Zhang et al. · Cellular Signalling · 0 citations