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Author

Deeksha Sharma

2 papers indexed here

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Open access Sep 2026

Targeting bromodomain and extra-terminal proteins reprograms macrophages and inhibits breast cancer progression

Introduction Breast cancer (BC) remains a leading cause of cancer-related deaths, with resistance to therapy driving tumor progression. While immune checkpoint inhibitor (ICI) therapy is effective in some breast cancers, the heterogeneity of treatment responses is partly driven by cancer stem cells (CSCs) and an immuno...

Deeksha Sharma, Cody G. Hager, Grace G. Bushnell et al. · 1 citation
Open access Sep 2026

BET Protein Degrader ZBC260 Induces Tumor Vascular Reprogramming Through Endothelial Cell Remodeling

The transcriptomic and cell–cell communication changes observed are consistent with the establishment of a more immune-permissive tumor microenvironment, supporting the potential of BET degradation as a strategy to complement immunotherapy and improve therapeutic responsiveness in breast cancer.

Deeksha Sharma, Cody G. Hager, Max S. Wicha et al. · 0 citations

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