AtMYB11/12/111 transcription factors regulate nicotine biosynthesis and enhance defense responses in tobacco.
It is demonstrated that the Arabidopsis R2R3-MYB transcription factors AtMYB11, AtMYB12, and AtMYB111 function as positive regulators of nicotine biosynthesis in tobacco for the first time and highlights their potential for metabolic engineering of nicotine content and stress resilience in tobacco.