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Deepa Cherian and Dr. Rakesh Kumar Jat

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Review Open access Sep 2026

Comparative Assessment of Nanocrystal and Inclusion Complex Technologies for Solubility Enhancement of BCS Class II Drug Molecules

A large proportion of new chemical entities entering pharmaceutical development pipelines exhibit poor aqueous solubility while retaining high intestinal permeability, placing them in Biopharmaceutics Classification System (BCS) Class II. For these molecules, dissolution rather than membrane permeation is the rate-limi...

Deepa Cherian and Dr. Rakesh Kumar Jat · 0 citations
Open access Sep 2026

Application of Self-Nanoemulsifying Drug Delivery Systems in Enhancing Dissolution Rate and Pharmacokinetic Performance of Poorly Water-Soluble Pharmaceuticals

Poor aqueous solubility remains the single most common cause of variable and incomplete oral absorption among new chemical entities, with a substantial proportion of marketed and pipeline molecules falling under Biopharmaceutics Classification System (BCS) classes II and IV. Self-nanoemulsifying drug delivery systems (...

Deepa Cherian and Dr. Rakesh Kumar Jat · 0 citations

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