Author

Deepani W. Poramba-Liyanage

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Open access Sep 2026

Single-cell multi-omics defines H3K27me3 remodelling in intervertebral disc degeneration with implications for regenerative intervention

This study demonstrates that eliminating repressive histone marks, together with CRISPR-mediated gene transactivation, enhances TBXT gene expression in human NPCs derived from degenerated aged discs.

Deepani W. Poramba-Liyanage, Xiao-Le Tong, F. Riemers et al. · Bone Research · 0 citations

Open access Aug 2026

CRISPR activation reveals SOX5/6/9 as key transcriptional regulators directing iPSC-derived cells toward a notochordal lineage

This study demonstrates the integration of CRISPRa with single-cell technologies as a powerful platform for investigating and enriching iPSC-derived NCs, supporting future regenerative strategies across various fields.

Xiao-Le Tong, Marieke Visscher, F. Riemers et al. · Stem Cell Reports · 0 citations