Deng-Feng Gao

Combination of Blastocyst Complementation and Omics Allows Fast Evaluation of Human Pathogenic Mutations in Mice.

RATIONALE Development of in vivo animal models carrying patient-derived pathogenic gene variants is critical for dissecting molecular mechanisms critical for human lung diseases. However, generation of new murine lines is costly and time-consuming, often requiring years before mechanistic studies can begin. OBJECTIVE...