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Oct 2026

NFS1 as a Metabolic Vulnerability in Acute Myeloid Leukemia Through Iron Dysregulation and STAT1/IFIT2-Associated Signaling.

Acute myeloid leukemia (AML) is a metabolically heterogeneous malignancy with poor outcomes and limited durable therapeutic options. We investigated NFS1, a key enzyme involved in iron-sulfur cluster biogenesis, as a potential metabolic vulnerability in AML. NFS1 was overexpressed in AML samples, and higher expression...

Ying Liu, Zi-Yi Wei, Bing-Xin Qian et al. · 0 citations
Open access Jul 2026

Serglycin-ROS axis mediates synergistic lethality of PI3Kγ inhibition and Azacitidine in TP53-mutated AML.

PURPOSE To investigate novel combination strategies for TP53-mutated acute myeloid leukemia (AML), focusing on the potential synergy between PI3Kγ inhibition and Azacitidine, and to elucidate the underlying molecular mechanisms. MATERIALS AND METHODS We detected the expression of PI3Kγ (PIK3CG/PIK3R5) in TP53 mutant...

Guiqin Huang, Xiao-ya Cai, Yeming Zhou et al. · 0 citations

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