Open access
Jul 2026
Perioperative myeloid cell remodeling shapes CAR-T cell efficacy in glioblastoma
Glioblastoma (GBM) is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that constrains the efficacy of chimeric antigen receptor (CAR)-T cell therapy. Here, we show that surgical resection in both male mice and human GBM ex vivo induces a rapid and sustained remodeling of the TME, marked by...
Martin Pedard, Luis Castillo Cantero, Ali Ghasemi et al.
· Nature Communications · 0 citations