Aug 2026
Optimized AAV to express the unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease features in mouse models
Treatment of 5xFAD mice with Proteostaser-1 improved spatial learning and synaptic plasticity, and reduced the deposition of amyloid plaques in the brain, which support the therapeutic potential of the UPR as a strategy to ameliorate AD features and sustain synaptic function.
Mei Li Diaz, Giovanni Tamburini, Diego Arriagada et al.
· bioRxiv · 0 citations