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Author

Dennis Hanke

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Open access Oct 2026

Population size modulates the transition from gene amplification-mediated heteroresistance to stable resistance

Heteroresistance is characterized by antibiotic-resistant subpopulations which can be underpinned by reversible gene duplication-amplification (GDA) of antibiotic resistance genes. It is often considered a precursor of stable resistance mutations. We investigated the evolutionary dynamics between GDA-mediated heterores...

Johannes Kupke, Yuwen Fang, F. Ghazisaeedi et al. · 0 citations

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