In silico evaluation of p-ANAPL library against inhibiting the cognate isoform cyclooxygenase Cox-2
This study employed a comprehensive in silico pipeline to screen the Pan-African Natural Products Library (p-ANAPL) for potential COX-2 inhibitors with optimised pharmacokinetic and safety profiles. A rigorous ADMET filtering workflow was first applied to prioritize compounds with favourable drug-likeness and low toxic...