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Dharmendra Kumar

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Review Aug 2026

Mechanistic Insights, Structure-activity Relationships, and Safety Profile of Mitragyna speciosa Alkaloids

Mitragyna speciosa, better known as kratom, is a traditional medicinal plant from Southeast Asia. It contains mainly two indole alkaloids, mitragynine and 7- hydroxymitragynine, which differ from classical opioids by displaying a unique mode of opioid pharmacology. This review discusses the chemistry, Structure-Act...

V. Verma, Dharmendra Kumar · 0 citations
Review Aug 2026

Targeting Klotho Signaling for Neuroprotection in Huntington's Disease: A Comprehensive Review.

Klotho is a promising neurochemical modulator with disease-modifying properties in HD, and its multifunctional protective activities are consistent with important pathological markers of HD, necessitating more preclinical and clinical studies to confirm its translational value.

Shikha Singh, Avnesh Kumar, Falguni Goel et al. · 0 citations
Review Jul 2026

Gene/Genome Editing in Cardiovascular Biology and Disease.

Genome editing is a paradigm-shifting development within the field of cardiology that promises a long-term genetic remedy, yet further optimization and development within genome editing and its guidelines will be important for making such a paradigm shift successful.

Tushar Verma, R. Singh, M. Chaudhary et al. · 0 citations

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