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Author

Dhiman Ghosh

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Open access Sep 2026

Terazosin Activates or Inhibits Human Phosphoglycerate Kinase 1 on a Dose-Dependent Basis: Mechanistic and Structural Insights by NMR

Phosphoglycerate kinase 1 (PGK1) is a key metabolic enzyme responsible for ATP production, and its dysregulation is linked to the Warburg effect in cancer and to neurodegenerative diseases such as Parkinson’s. Recent studies indicate that terazosin, an FDA-approved drug, enhances PGK1-mediated ATP production. However...

M. Bütikofer, Felix Torres, Dhiman Ghosh et al. · 0 citations
Open access Jul 2026

On the Polymorph-Selection Determinants of α- Synuclein Amyloid Fibrils Studied at Atomic Resolution

Alpha-synuclein is an intensely studied intrinsically disordered protein whose aggregation into amyloid fibrils is connected to the progression of several neurodegenerative diseases, most commonly Parkinson’s Disease. A remarkable feature that has emerged from this research is how easy it is to induce the protein to ag...

Lukas Frey, D. Rhyner, Witek Kwiatkowski et al. · 1 citation

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