Stimuli-Responsive Nanocarriers in Oncology: Tumor Microenvironment Triggers, Overcoming Biological Barriers, and Clinical Reality
Conventional anticancer nano-therapies often rely on passive accumulation through the enhanced permeability and retention (EPR) effect, resulting in insufficient penetration of tumor tissue and heterogeneous cellular uptake. Smart nanocarriers that are able to respond to specific stimuli through conformational, charge-...