Author

Di Xiao

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Open access Jul 2026

The novel biguanide derivative 4C synergizes with talazoparib by inducing ferroptosis via the SREBP1/FASN/ SLC7A11/GPX4 axis in bladder cancer

It is demonstrated that the combination of 4C and talazoparib induces ferroptosis via the SREBP1/FASN axis, providing a promising novel combination therapeutic strategy for the treatment of BC.

Jia Yao, Weifan Wang, Duo Li et al. · Cell Death Discovery · 0 citations

Aug 2026

Undescribed cucurbitacin-type triterpenoids from the roots of Trichosanthes cucumeroides with antitumor effects, and their molecular docking studies.

This study aimed to isolate compounds from the roots of T. cucumeroides and to evaluate their cytotoxic activities and potential protein-binding interactions, and found that some compounds exhibited significant effects with IC50 values from 0.051 to >20 μM.

Muhammad Aamer, Fei-Bing Huang, Di Xiao et al. · Bioorganic chemistry (Print) · 0 citations