Targeting IGF2BP3-driven CSF1/CSF1R signaling disrupts the positive feedback loop between tumor cells and macrophages and inhibits HCC progression.
AIMS Hepatocellular carcinoma (HCC) remains a major global malignancy characterized by a complex tumor microenvironment (TME) and poor prognosis. Expansion and pro-tumoral polarization of tumor-associated macrophages (TAMs) are principal contributors to malignant progression, but the precise regulatory mechanisms under...