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Diao Yan

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Open access Aug 2026

Nanobodies targeting SARS-CoV-2 papain-like protease exert dual antiviral and anti-inflammatory effects

It is demonstrated that nanobodies targeting the PLpro/ISG15 interface can achieve synergistic antiviral and immunomodulatory effects, providing a proof-of-concept for a novel therapeutic approach to combat SARS-CoV-2 and potentially other emerging coronaviruses.

Guo-Long Liu, Jiantao Chen, Fang Wu et al. · 0 citations