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Dibyam Debasish Sahu

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Sep 2026

Biologically-synthesized zinc oxide nanoparticle-based α-synuclein nanoformulation mitigates Parkinson's disease progression in Drosophila melanogaster.

Parkinson's disease (PD) is a synucleinopathy characterized by the accumulation of alpha-synuclein (αS) amyloid aggregates and loss of dopaminergic neurons. Evidence suggests that PD originates in intestine and progresses to brain via the vagus nerve. Thus, initially, the potential of orally-fed αS pre-formed fibrils (...

Sonali Jena, K. Subham, Harshit Kalra et al. · 0 citations
Review 2026

Glial control of extracellular α-synuclein propagation in LRRK2 Parkinson's disease.

This review synthesises current evidence on how mutations in Leucine-Rich Repeat Kinase 2 (LRRK2), the most common genetic cause of familial PD, fundamentally corrupt glial handling of extracellular α-synuclein and evaluates emerging therapeutic strategies targeting LRRK2 kinase activity, NLRP3 inflammasome activation,...

Indrani Datta, Dibyam Debasish Sahu · 0 citations

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