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Diego Arriagada

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Aug 2026

Optimized AAV to express the unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease features in mouse models

Treatment of 5xFAD mice with Proteostaser-1 improved spatial learning and synaptic plasticity, and reduced the deposition of amyloid plaques in the brain, which support the therapeutic potential of the UPR as a strategy to ameliorate AD features and sustain synaptic function.

Mei Li Diaz, Giovanni Tamburini, Diego Arriagada et al. · 0 citations