Open access
Sep 2026
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4.
The cyclin E-cyclin-dependent kinase 2 (CDK2) complex is a component of mammalian cell-cycle machinery that drives cell division. Hyperactivation of cyclin E-CDK2 is frequent in human cancers. Small-molecule CDK2 inhibitors are tested in clinical trials for cancer patients. Here, we report that cyclin E-CDK2 has a cell...
Chen Chu, Shanshan Zheng, Ning Mitchell et al.
· Molecules and Cells · 1 citation