Open access
Oct 2026
A peptidomimetic inhibitor blocks Vibrio cholerae adhesin FrhA
Ming-Yu Wang, Charity Yongo-Luwawa, Laura Zhang et al.
· bioRxiv · 0 citations
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Open access
Oct 2026
Loss of function variants in ADAMTS6: a new connective tissue disorder with heart defect, aortic aneurysm and neurodevelopmental features.
PURPOSE Marfan syndrome, Loeys-Dietz syndrome, and heritable thoracic aortic aneurysms and dissections (hTAAD) are autosomal dominant connective-tissue disorders with overlapping features and considerable genetic variability. Many cases arise from pathogenic variants affecting extracellular matrix (ECM) components or T...
Júlia Huguet Herrero, P. Arnaud, A. Bibimbou et al.
· Genetics in Medicine · 0 citations
Open access
Aug 2026
Single-Cell Proteomics Uncovers Cell-Specific Proteins in Vascular Health and Marfan Syndrome Disease
The first human single-cell proteomic atlas of the aorta is established, altered FBN1 protein regulation in both human and mouse MFS is revealed, and single-cell proteomics is position as a transformative framework for decoding vascular plasticity and identifying actionable effectors in disease.
Junedh M. Amrute, Lihua Jiang, Nikhita Bolar et al.
· Arteriosclerosis, Thrombosis... · 0 citations