Phylogenetic distribution of PB2 E627K and D701N mutations in global H5N1 influenza A viruses
Objective: This study investigates the phylogenetic distribution of the mammalian adaptation–associated E627K and D701N mutations in the PB2 gene of H5N1 influenza A virus. It aims to determine whether these substitutions cluster within specific viral lineages or arise independently across distinct genetic backgrounds....