Integrative transcriptomic and regulatory network analysis reveals associations of seven proposed risk genes with immune-related molecular features in Alzheimer's disease.
BackgroundAlzheimer's disease (AD) involves neuroinflammation influenced by genetic and immune dysregulation. Seven proposed AD risk genes (CACNA2D3, EPB41L2, INPP5D, MYO1F, RBM47, SSH2, TBXAS1) have been identified, but their associations with the immune microenvironment (IME) remain unclear.ObjectiveThis study invest...