Author

Dinesh Babu

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Open access Sep 2026

Edaravone as an antioxidant adjuvant to attenuate clozapine toxicity in vitro.

Despite being the gold-standard therapy for treatment-resistant schizophrenia, clozapine use remains constrained by the risk of rare but serious adverse drug reactions, including severe neutropenia and agranulocytosis. Neutrophil myeloperoxidase (MPO)-mediated bioactivation of clozapine to reactive metabolites has long...

Dinesh Babu, Thom H. Le, Huan Liu et al. · Toxicology Letters · 1 citation

Oct 2026

Decoding the Molecular Target Landscape of Chalcones: An Integrated Cheminformatics Analysis Using PubChem Patent Data, Protein Target Profiling, and Bioassay Activity Mapping.

BACKGROUND Chalcones are α,β-unsaturated ketone scaffolds with broad documented bioactivity. No prior study has simultaneously integrated structural validation, PAINS assessment, chemical-space clustering, human-target classification, bioassay hit-rate benchmarking, and patent analysis within a single computational fra...

S. Arulsamy, Kiruthiga Natarajan, S. K. Krishnan et al. · Current Drug Targets · 0 citations