Sirt3 attenuates LPS-induced mitochondrial fission in renal tubular epithelial cells through the AMPK-Drp1 pathway.
Sepsis-associated acute kidney injury (S-AKI) is characterized by profound tubular epithelial cell injury and mitochondrial dysfunction, yet the mechanisms linking mitochondrial dynamics to renal damage remain incompletely defined. This study investigated the role of sirtuin 3 (Sirt3) in regulating mitochondrial dynami...