Open access
Oct 2026
Single-cell and spatial multi-omics combined with machine learning to unravel the heterogeneity of cholangiocarcinoma and the WFDC3-mediated prognostic regulatory mechanisms
Intrahepatic cholangiocarcinoma (ICC) exhibits substantial cellular heterogeneity and a complex tumor microenvironment (TME), contributing to poor clinical outcomes. Effective prognostic biomarkers and a deeper understanding of the cellular ecosystems associated with high-risk disease remain urgently needed....
Zhen-Chen Zhu, Tao Jiang, Qiu-Hua Liu et al.
· Frontiers in Immunology · 0 citations