Oct 2026
The divergent 3D genome landscapes of aging and neurodegenerative mouse models.
Chromatin structure is essential for gene regulation and genome stability, as neurons must preserve their 3D genome organization throughout life. This structure gradually deteriorates with aging and is further disrupted in neurodegenerative diseases. To investigate whether aging and neurodegeneration share early chroma...
E. Kashuk, Dmitrii Smirnov, Ekaterina Eremenko et al.
· Genome Research · 0 citations