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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Dmitry Lyumkis

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2 papers indexed here

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Open access Sep 2026

Structural basis of transcription of the hachimoji eight-letter alphabet by E. coli RNA polymerase

Expanded genetic alphabets with synthetic nucleotides can greatly increase the chemical diversity of nucleic acids, enabling new molecular functions. Because cellular transcription is executed by multi-subunit RNA polymerases, the compatibility of unnatural base pairs with this machinery is essential for engineering ex...

Qing-Rong Li, Hyo-Joong Kim, Yan Liu et al. · 0 citations
Open access Aug 2026

Structure of an RNA polymerase ribozyme replication complex

The structure of such a polymerase ribozyme bound to RNA substrates comprising the template, primer, and nucleoside triphosphate (NTP) analog is presented, revealing how directed evolution shaped flanking elements around a highly conserved catalytic core derived from the ancestral class I ligase ribozyme.

Timothy S. Strutzenberg, David P. Horning, Wesley G. Cochrane et al. · 0 citations

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