Author

Do-Gyeong Kim

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Open access Sep 2026

Lapatinib suppresses cysteine deprivation-induced ferroptotic cell death by modulating mitochondrial function

Lapatinib exerts context-dependent effects, suppressing cysteine deprivation- induced ferroptosis despite inducing a mild ferroptotic phenotype when used alone, and attenuates cysteine deprivation-induced mitochondrial metabolic activation.

Gyeongmi Kim, S. Jang, Do-Gyeong Kim et al. · Medical Oncology · 0 citations

Open access Sep 2026

Tubacin induces TFEB-dependent ferritinophagy independently of HDAC6 and sensitizes cancer cells to ferroptosis under GSH-GPX4 axis disruption.

These findings identify TFEB-driven lysosomal activation and ferritinophagy as a critical determinant of ferroptotic sensitivity under redox imbalance and suggest that pharmacological modulation of TFEB-lysosomal function by tubacin may represent a potential strategy for enhancing ferroptosis-based cancer therapy.

Gyeongmi Kim, S. Jang, Do-Gyeong Kim et al. · Biochemical Pharmacology · 0 citations